Hexamethylene Diisocyanate CAS#822-06-0
High Reactivity for Chemical Synthesis: Hexamethylene diisocyanate (HDI) reacts slowly with water, making it suitable for controlled chemical reactions in polymer and coating applications.
Stable Liquid Form: Exists as a colorless or slightly yellow liquid at room temperature, facilitating handling and storage.
Wide Thermal Range: With a melting point of −67 to −55°C and a boiling point of 255–261°C, HDI is stable over a broad temperature range.
Low Solubility in Water: Slight water solubility allows it to maintain performance in formulations where minimal hydrolysis is desired.
Hexamethylene diisocyanate is a colorless to slightly yellow liquid with a pungent odor. It is slightly soluble in water and reacts slowly upon contact. The compound has a relative density of approximately 1.05 at room temperature, a boiling point of 255–261°C, and a melting (freezing) point of −67 to −55°C. The saturated vapor concentrations are 46 mg/m³ at 20°C and 137 mg/m³ at 30°C.
Parameters
| Melting point | -55°C |
| Boiling point | 82-85 °C/0.1 mmHg |
| density | 1.047 g/mL at 20 °C (lit.) 1.047 g/mL at 20 °C |
| vapor pressure | 0.05 mm Hg ( 25 °C) |
| refractive index | n20/D 1.453 |
| Fp | 248 °F |
| storage temp. | Store below +30°C. |
| form | Liquid |
| Specific Gravity | 1.05 |
| color | Clear colorless to slightly yellow |
| explosive limit | 0.9-9.5%(V) |
| Water Solubility | Reacts |
| Sensitive | Moisture Sensitive |
| BRN | 956709 |
| Exposure limits | TLV-TWA 0.0343 mg/m3 (0.005 ppm) (ACGIH). |
| Stability: | Stable. Moisture sensitive. Combustible. Incompatible with strong oxidizing agents, strong bases, amines, acids. May react explosively with alcohols in the presence of base without a diluting solvent. Heating above 200 C may cause polymerization. |
| InChIKey | RRAMGCGOFNQTLD-UHFFFAOYSA-N |
| LogP | 3.2 at 20℃ |
| CAS DataBase Reference | 822-06-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,6-Hexamethylene diisocyanate(822-06-0) |
| EPA Substance Registry System | Hexamethylene-1,6-diisocyanate (822-06-0) |
| Hazard Codes | T,T+,F |
| Risk Statements | 23-36/37/38-42/43-41-34-26-22-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-28-38-45-28A-36/37/39-23-36/37-16-7 |
| OEB | D |
| OEL | TWA: 0.005 ppm (0.035 mg/m3), Ceiling: 0.020 ppm (0.140 mg/m3) [10-minute] |
| RIDADR | UN 2281 6.1/PG 2 |
| WGK Germany | 1 |
| RTECS | MO1740000 |
| F | 10-19-21 |
| Autoignition Temperature | 454 °C |
| TSCA | Yes |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29291090 |
| Hazardous Substances Data | 822-06-0(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 746 mg/kg LD50 dermal Rabbit 570 mg/kg |
Product Application of Hexamethylene Diisocyanate (CAS 822-06-0)
Hexamethylene diisocyanate is widely used as a pharmaceutical intermediate and in the production of carbonyl compounds, isocyanates, and other organic chemical raw materials. It serves as a key building block for organic synthesis, fine chemicals, esters, and nitrogen-containing compounds. Additionally, it is utilized in polymer science, material intermediates, monomers, and various chemical reagents and standard products for research and industrial applications.
