p-Cresol CAS#106-44-5
Versatile Solubility; p-Cresol is readily soluble in caustic alkalis and common organic solvents, and partially soluble in water, making it suitable for various industrial and chemical applications.
Stable Physical Properties: It has a well-defined melting point, boiling point, and flash point, ensuring reliable handling and processing.
Naturally Occurring Compound: p-Cresol is found naturally in ylang-ylang oil, strawberries, cheese, coffee, and cocoa, which supports its use in flavor, fragrance, and natural product applications.
Distinctive Odor for Functional Use: Its smoky, herbal odor can be leveraged in fragrances, flavorings, and related specialty applications.
p-Cresol is a colorless to pink crystal with a smoky, herbal odor. Its relative density (d420) is 1.0178, refractive index (nD20) is 1.5312, melting point is 34.8℃, boiling point is 201.9℃, and flash point is 86.1℃. It is soluble in water (2.3%/40℃) and readily soluble in caustic alkalis and common organic solvents. It is found naturally in ylang-ylang oil, strawberries, cheese, coffee, cocoa, etc.
| Melting point | 32-34 °C(lit.) |
| Boiling point | 202 °C(lit.) |
| Density | 1.034 g/mL at 25 °C(lit.) |
| Vapor density | 3.72 (vs air) |
| Vapor pressure | 1 mm Hg (20°C) |
| Refractive index | nD20 1.5395 |
| FEMA | 2337 | P-CRESOL |
| Flash point | 193 °F |
| Storage conditions | Store below +30°C. |
| Solubility | 20g/l |
| Acidity coefficient (pKa) | 10.17(at 25℃) |
| Form | Crystalline solid or liquid |
| Color | Colorless to pale yellow, may darken upon exposure to light |
| Specific gravity | 1.0341 (20/4℃) |
| Odor | 0.10% dipropylene glycol solution. Phenolic odor. |
| Fragrance type | phenolic |
| Biological origin | synthetic |
| Water solubility | 20 g/L (20 °C) |
| Sensitivity | Light Sensitive |
| Merck | 142,579 |
| Henry's Law Constant | 6.17 at 20.00 °C, 9.31 at 25.00 °C (dynamic equilibrium system-GC, Feigenbrugel et al., 2004a) |
| Dielectric constant | 5.6 (21.0℃) |
| Stability | Stable. Flammable. Incompatible with strong oxidizers. Sensitive to air and light. Hygroscopic. |
Uses: Bactericide, fungicide, organic synthesis. This product is a raw material for manufacturing the antioxidant 2,6-di-tert-butyl-p-cresol and rubber antioxidants. It is also an important basic raw material for the production of pharmaceutical TMP and dye clindamycin sulfonic acid. P-cresol is an intermediate chemical in the production of the fungicide methyl thiophanate, the insecticides flufenoxuron and fenpropathrin, and also an intermediate in the production of the antioxidant additives 2,6-di-tert-butyl-4-methylphenol and p-hydroxybenzaldehyde. P-cresol is used as a raw material for manufacturing the antioxidant 264 (2,6-di-tert-butyl-p-cresol) and rubber antioxidants. In the plastics industry, it can be used to manufacture phenolic resins and plasticizers. In medicine, it is used as a disinfectant. In addition, it can be used as a raw material for dyes and pesticides.
