Glycvrrhizic acid ammonium salt CAS#53956-04-0
Extremely Sweet Taste – Ammonium glycyrrhizinate is approximately 200 times sweeter than sucrose, making it a highly effective natural sweetener.
Versatile Food Application – Widely used in food additives for products such as canned meats, seasonings, candies, biscuits, preserved fruits, and beverages.
Glucocorticoid-Like Activity – Exhibits anti-inflammatory, anti-allergic, and membrane-protective effects without the common side effects of corticosteroids.
Hepatic Enzyme Modulation – Strong affinity for hepatic sterol-metabolizing enzymes, inhibiting the inactivation of cortisol and aldosterone, supporting physiological balance.
Product Description of Glycyrrhizic Acid Ammonium Salt CAS#53956-04-0
Ammonium glycyrrhizinate is a highly potent sweetener, approximately 200 times sweeter than sucrose. It is widely used in food additives and can be applied in products such as canned meats, seasonings, candies, biscuits, preserved fruits, and beverages.
Monoammonium glycyrrhizinate exhibits strong affinity for hepatic sterol-metabolizing enzymes, thereby inhibiting the inactivation of cortisol and aldosterone. Upon administration, it provides notable glucocorticoid-like effects, including anti-inflammatory activity, anti-allergic properties, and protection of membrane structures, without causing the typical side effects associated with corticosteroids.
Parameters
| Melting point | >200°C (dec.) |
| Boiling point | 768.56°C (rough estimate) |
| density | 1.1846 (rough estimate) |
| FEMA | 2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) |
| refractive index | 49 ° (C=1.5, EtOH) |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides. |
| form | Powder or Crystals |
| color | Yellow to yellow-green |
| Odor | bland |
| optical activity | [α]20/D +48±4°, c = 1% in ethanol: water (1:1) |
| BRN | 3897076 |
| Stability: | Hygroscopic |
| InChIKey | ILRKKHJEINIICQ-YDYGGSECSA-N |
| LogP | -0.9 |
| CAS DataBase Reference | 53956-04-0 |
| EPA Substance Registry System | alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt (53956-04-0) |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 2 |
| RTECS | LZ6500000 |
| F | 3-10 |
| HS Code | 29389090 |
Product Application of Glycyrrhizic Acid Ammonium Salt CAS#53956-04-0
Ammonium glycyrrhizinate is utilized in the synthesis of polyion complex nanocarriers, serving as a template for designing other negatively charged, water-soluble drugs, particularly in combination with anti-inflammatory compounds. Glycyrrhizic acid ammonium salt, derived from licorice flavonoids, also functions as a flavoring and sweetening agent, offering a mild licorice taste with intense, well-rounded sweetness.
It is soluble in water, glycerin, and propylene glycol, and exhibits good thermal stability, although prolonged heating can lead to degradation. It remains stable within a pH range of 3.5–9, but may precipitate below pH 3.5. This compound is suitable for use in beverages, desserts, confectionery products, soups, and salad dressings.
