β-Estradiol CAS#50-28-2
Key natural estrogen hormone – Estradiol is the most important and biologically active estrogen in the human body.
Naturally derived steroid hormone – Primarily secreted by ovarian follicles, corpus luteum, and the placenta during pregnancy.
High biological activity – Exhibits strong physiological activity among all estrogen hormones.
Essential role in reproductive health – Plays a central role in regulating female reproductive endocrine functions.
Product Description of β-Estradiol CAS#50-28-2
Estradiol is a steroid hormone primarily secreted by ovarian follicles, the corpus luteum, and the placenta during pregnancy. It is the most important and biologically active hormone among estrogens.
Parameters
| Melting point | 178-179 °C(lit.) |
| alpha | D25 +76 to +83° (dioxane) |
| Boiling point | 355.44°C (rough estimate) |
| density | 1.0708 (rough estimate) |
| refractive index | 80.4 ° (C=1, Dioxane) |
| Fp | 2℃ |
| storage temp. | room temp |
| solubility | Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride. |
| pka | pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate) |
| form | powder |
| color | White to off-white |
| biological source | synthetic (organic) |
| Water Solubility | Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils. |
| Merck | 143703 |
| BRN | 1914275 |
| BCS Class | 1 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | VOXZDWNPVJITMN-ZBRFXRBCSA-N |
| CAS DataBase Reference | 50-28-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2) |
| EPA Substance Registry System | Estradiol (50-28-2) |
Safety Information
| Hazard Codes | T,Xn,F |
| Risk Statements | 60-61-45-63-64-40-36-20/21/22-11-48 |
| Safety Statements | 53-22-36/37/39-45-36/37-26-16-36-20 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | KG2975000 |
| F | 45879 |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29372390 |
| Hazardous Substances Data | 50-28-2(Hazardous Substances Data) |
| Toxicity | LD50 subcutaneous in rat: > 300mg/kg |
Product Application of β-Estradiol CAS#50-28-2
Estradiol is used as an estrogen medication for the treatment of functional uterine bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. It helps promote and regulate the normal development of female reproductive organs and secondary sexual characteristics. It can also stimulate the growth and proliferation of mammary ducts; however, at high doses, it may inhibit prolactin release from the anterior pituitary gland, thereby reducing milk secretion, and is also used to suppress lactation.
Potential adverse effects include nausea, vomiting, and bleeding caused by excessive endometrial proliferation. It should be used with caution in patients with hepatic or renal impairment and must not be applied to the breast, vulva, or vaginal mucosa.
