2-Phenoxyethanol CAS#122-99-6
Broad-Spectrum Preservative – Phenoxyethanol is an effective bactericide, commonly used to prevent microbial growth in cosmetics, vaccines, and pharmaceutical products.
Versatile Application – It is widely used in dermatological products, including skin creams and sunscreens, as well as in vaccines and pharmaceutical formulations.
Stable and Safe Chemical – Phenoxyethanol is a colorless, oily liquid that is compatible with a variety of formulations and can be safely used as a preservative.
Synergistic Antimicrobial Effect – Often used in combination with quaternary ammonium compounds, Phenoxyethanol enhances antibacterial effectiveness.
Product Description of 2-Phenoxyethanol CAS# 122-99-6
2-Phenoxyethanol is an organic chemical compound belonging to the glycol ether family, commonly utilized in dermatological products like skin creams and sunscreens. It appears as a colorless, oily liquid and acts as a bactericide, often in combination with quaternary ammonium compounds. This compound serves as a preservative in a variety of applications, including cosmetics, vaccines, and pharmaceutical products.
2-Phenoxyethanol Chemical Properties
| Melting point | 11-13 °C (lit.) |
| Boiling point | 247 °C (lit.) |
| density | 1.102 g/mL at 25 °C (lit.) |
| vapor density | 4.8 (vs air) |
| vapor pressure | 0.01 mm Hg ( 20 °C) |
| refractive index | n20/D 1.539 |
| FEMA | 4620 | 2-PHENOXYETHANOL |
| Fp | >230 °F |
| storage temp. | Store below +30°C. |
| solubility | soluble, clear, colorless to very faintly yellow |
| pka | 14.36±0.10(Predicted) |
| form | Liquid |
| color | Clear colorless |
| Specific Gravity | 1.109 (20/4℃) |
| Odor | Faint aromatic odor |
| PH Range | 7 at 10 g/l at 23 °C |
| PH | 7 (10g/l, H2O, 23℃) |
| explosive limit | 1.4-9.0%(V) |
| Odor Type | floral |
| Water Solubility | 30 g/L (20 ºC) |
| Merck | 147257 |
| BRN | 1364011 |
| InChIKey | QCDWFXQBSFUVSP-UHFFFAOYSA-N |
| LogP | 1.2 at 23℃ |
| CAS DataBase Reference | 122-99-6(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Phenoxyethanol(122-99-6) |
| EPA Substance Registry System | Ethylene glycol monophenyl ether (122-99-6) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36-R36-R22 |
| Safety Statements | 26-S26 |
| WGK Germany | 1 |
| RTECS | KM0350000 |
| Autoignition Temperature | 535 °C DIN 51794 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29094990 |
| Hazardous Substances Data | 122-99-6(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 1850 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
Product Application of 2-Phenoxyethanol CAS# 122-99-6
Phenoxyethanol is a versatile preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It exhibits a relatively low sensitization potential in leave-on cosmetic products. This compound can be applied at concentrations ranging from 0.5% to 2.0%, either alone or in combination with other preservatives such as sorbic acid or parabens. Additionally, phenoxyethanol serves as a solvent in products like aftershaves, face and hair lotions, shampoos, and all types of skin creams. It can be produced from phenol.
