Trifluoromethanesulfonic acid CAS#1493-13-6
Extremely Strong Acid ： Triflic acid is recognized as one of the strongest acids, belonging to the superacid class.
High Thermal and Chemical Stability ： It is non-oxidizing, thermally stable, and resistant to both oxidation and reduction.
Versatile in Fine Chemical and Pharmaceutical Synthesis ： Used in the production of pharmaceuticals, agricultural chemicals, polymers, nucleosides, antibiotics, steroids, proteins, and glycosides.
Effective Anhydrous Form : The anhydrous form is widely utilized in fine chemical synthesis due to its reactivity and utility.
Products Description of Trifluoromethanesulfonic acid CAS#1493-13-6
Trifluoromethanesulfonic acid, commonly known as triflic acid, TFMS, TFSA, HOTf, or TfOH, is a sulfonic acid with the chemical formula CF₃SO₃H. It is considered one of the strongest acids and belongs to the class of “superacids.” This compound is widely used in the production of pharmaceuticals, agricultural chemicals, and polymers. Its anhydrous form is particularly valuable in fine chemical synthesis. Triflic acid is non-oxidizing, exhibits high thermal stability, and is resistant to both oxidation and reduction, making it one of the most versatile superacids. In the pharmaceutical industry, it is employed in the synthesis of various drug classes, including nucleosides, antibiotics, steroids, proteins, and glycosides. Triflic anhydride is highly reactive with water and possesses a notable toxicity profile.
Parameters
| Melting point | -40 °C |
| Boiling point | 162 °C (lit.) |
| density | 1.696 g/mL at 25 °C (lit.) |
| vapor density | 5.2 (vs air) |
| vapor pressure | 8 mm Hg ( 25 °C) |
| refractive index | n20/D 1.327(lit.) |
| RTECS | PB2771000 |
| Fp | None |
| storage temp. | Store below +30°C. |
| solubility | Miscible in H<sub>2</sub>O |
| pka | -14(at 25℃) |
| form | Fuming Liquid |
| color | slightly brown |
| Specific Gravity | 1.696 |
| PH | <1 (H2O) |
| Water Solubility | SOLUBLE |
| Sensitive | Hygroscopic |
| Merck | 149,676 |
| BRN | 1812100 |
| Stability: | Stable. Incompatible with acids, alkalis, metals. |
| InChIKey | ITMCEJHCFYSIIV-UHFFFAOYSA-N |
| LogP | 0.3 at 25℃ |
| CAS DataBase Reference | 1493-13-6(CAS DataBase Reference) |
| NIST Chemistry Reference | CF3SO3H(1493-13-6) |
| EPA Substance Registry System | Methanesulfonic acid, trifluoro- (1493-13-6) |
| Hazard Codes | C |
| Risk Statements | 21/22-35-10 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3265 8/PG 2 |
| WGK Germany | 2 |
| F | 3-10 |
| Hazard Note | Corrosive/Hygroscopic |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | II |
| HS Code | 29049020 |
| Toxicity | LD50 orally in Rabbit: 1605 mg/kg LD50 dermal Rat > 2000 mg/kg |
Product Application of Trifluoromethanesulfonic Acid CAS#1493-13-6
Trifluoromethanesulfonic acid functions as a catalyst in Friedel-Crafts–type acylation, alkylation, and polymerization reactions. It is also used as a solvent in electron spin resonance (ESR) studies and as a strong nonaqueous acid titrant. Additionally, it is employed alongside trifluoroacetic acid in solid-phase peptide synthesis. It is recognized as one of the strongest monoprotic acids available.
