N-Methylformamide CAS#123-39-7
Excellent Water Solubility: N-Methylformamide is a water-soluble organic solvent, making it suitable for a wide range of chemical and research applications.
Clear and Stable Liquid Form: It is supplied as a clear, colorless liquid with a slight amine odor, allowing for convenient handling and processing.
Effective Solvent Performance: Its solvent properties make it useful in various laboratory, chemical synthesis, and industrial processes.
Valuable Research Compound: N-Methylformamide has been studied as an adjuvant antineoplastic agent and is used in scientific research related to cellular glutathione depletion, reactive oxygen species (ROS), and tumor cell differentiation.
N-Methylformamide CAS#123-39-7
N-Methylformamide is a clear, colorless liquid with a mild amine-like odor. It is a water-miscible organic solvent commonly used in chemical and research applications.
In addition to its solvent properties, N-Methylformamide has been investigated as an adjuvant antineoplastic agent. It can reduce intracellular glutathione levels, a key component involved in protecting cells from reactive oxygen species (ROS) and other free radicals. This activity may enhance ionizing radiation-induced DNA cross-linking and promote the terminal differentiation of tumor cells. (NCI04)
N-Methylformamide Chemical Properties
| Melting point | -4 °C (lit.) |
| Boiling point | 198-199 °C (lit.) |
| density | 1.011 g/mL at 25 °C (lit.) |
| vapor pressure | 20Pa at 20℃ |
| refractive index | n20/D 1.432(lit.) |
| Fp | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in water, chloroform, alcohols, acetone, ethylacetate but not in diethyl ether and petroleum ether |
| pka | 16.48±0.23(Predicted) |
| form | Liquid |
| color | Clear colorless |
| Odor | strong odor |
| Relative polarity | 6.2 |
| Water Solubility | miscible |
| Merck | 146076 |
| BRN | 1098352 |
| Dielectric constant | 171 |
| Exposure limits | ACGIH: TWA 1 ppm (Skin) |
| InChI | 1S/C2H5NO/c1-3-2-4/h2H,1H3,(H,3,4) |
| InChIKey | ATHHXGZTWNVVOU-UHFFFAOYSA-N |
| SMILES | [H]C(=O)NC |
| LogP | -0.97 |
| CAS DataBase Reference | 123-39-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Formamide, N-methyl-(123-39-7) |
| EPA Substance Registry System | N-Methylformamide (123-39-7) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 61-21-R61-R21 |
| Safety Statements | 53-45-S53-S45 |
| WGK Germany | 1 |
| RTECS | LQ3000000 |
| TSCA | TSCA listed |
| PackingGroup | II |
| HS Code | 29241990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 |
| toxic compounds or compounds which causing chronic effects | |
| Hazard Classifications | Acute Tox. 4 Dermal |
| Repr. 1B | |
| Hazardous Substances Data | 123-39-7(Hazardous Substances Data) |
| Toxicity | LD50 in mice (mg/kg): 2300 i.p.; 2600 orally; 1580 i.v.; 2700 i.m. (Langdon) |
Product Application of N-Methylformamide CAS#123-39-7
N-Methylformamide is used in the preparation of methyl isocyanate and serves as an extraction solvent for aromatic hydrocarbons. It also functions as a ligand in coordination chemistry applications.
The compound is widely employed as a solvent in oil refining processes and in the manufacture of aluminum electrolytic capacitors. In addition, it is used as a reagent in organic synthesis and various chemical research activities.
Furthermore, N-Methylformamide has been investigated for its potential anticancer properties and serves as an intermediate in the synthesis of certain pharmaceutical compounds.
