Acrylamide CAS#79-06-1
High Solubility in Multiple Solvents: Easily dissolves in water and various organic solvents, enabling flexible processing and formulation.
Versatile Chemical Reactivity: Can be hydrolyzed into acrylic acid under acidic or alkaline conditions, offering adaptability in chemical synthesis.
Key Raw Material for Polymers: Serves as an essential precursor for the production of polyacrylamide and other important polymers.
Wide Derivative Compatibility: Acts as a fundamental monomer for a broad range of derivatives, including anionic, cationic, and N-substituted acrylamide compounds.
Acrylamide (CAS#79-06-1)
Acrylamide is a white crystalline compound that serves as a key raw material for the production of polyacrylamide. In solid form (commonly abbreviated as AM), it typically appears as colorless, transparent flakes, while the pure substance is a white crystalline solid. It is highly soluble in water, methanol, ethanol, and propanol, and slightly soluble in ethyl acetate, chloroform, and benzene. Under acidic or alkaline conditions, it can be hydrolyzed to form acrylic acid.
Acrylamide is also a fundamental parent compound for a wide range of monomers, including methacrylamide, AMPS (2-acrylamide-2-methylpropane sulfonic acid, an anionic monomer), DMC (methyl-acryloyloxyethyl trimethyl ammonium chloride, a cationic monomer), as well as various N-substituted acrylamide derivatives.
Acrylamide Chemical Properties
| Melting point | 82-86 °C(lit.) |
| Boiling point | 125 °C25 mm Hg(lit.) |
| bulk density | 500kg/m3 |
| density | 1,322 g/cm3 |
| vapor density | 2.45 (vs air) |
| vapor pressure | 0.03 mm Hg ( 40 °C) |
| refractive index | 1.46 |
| Fp | 138 °C |
| storage temp. | 2-8°C |
| solubility | 2040 g/L (25°C) |
| pka | 15.35±0.50(Predicted) |
| form | powder |
| color | White |
| Odor | Odorless solid |
| PH | 5.0-7.0 (50g/l, H2O, 20℃) |
| Water Solubility | Acrylamide is routinely tested at 250 mg/mL in water, giving a clear colorless solution. It is soluble at least to 40% (w/v) in water, and reportedly up to 215 g/100 mL in water at 30°C. |
| Sensitive | Light Sensitive |
| Merck | 14129 |
| BRN | 605349 |
| Henry's Law Constant | (x 10-9 atm?m3/mol): 3.03 at 20 °C (approximate - calculated from water solubility and vapor pressure) |
| Exposure limits | Potential occupational carcinogen. NIOSH REL: TWA 0.03, IDLH: 60; OSHA PEL: TWA 0.3; ACGIH TLV: TWA 0.03. |
| Stability: | Unstable. Do not heat above 50C. Explosive. Incompatible with acids, bases, oxidizing agents, reducing agents, iron and iron salts, copper, aluminium, brass, free radical initiators. Air sensitive. Hygroscopic. |
| Major Application | cleaning products |
| cosmetics | |
| environmental | |
| food and beverages | |
| personal care | |
| Cosmetic Ingredient Review (CIR) | Acrylamide (79-06-1) |
| InChI | 1S/C3H5NO/c1-2-3(4)5/h2H,1H2,(H2,4,5) |
| InChIKey | HRPVXLWXLXDGHG-UHFFFAOYSA-N |
| SMILES | NC(=O)C=C |
| LogP | -0.9 at 20℃ and pH7 |
| CAS DataBase Reference | 79-06-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Acrylamide(79-06-1) |
| IARC | 2A (Vol. 60, Sup 7) 1994 |
| EPA Substance Registry System | Acrylamide (79-06-1) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 45-46-20/21-25-36/38-43-48/23/24/25-62-48/20/21/22-22-24/25 |
| Safety Statements | 53-45-24-36/37/39-26-36/37 |
| RIDADR | UN 3426 6.1/PG 3 |
| OEB | D |
| OEL | TWA: 0.03 mg/m3 [skin] |
| WGK Germany | 3 |
| RTECS | AS3325000 |
| F | 46244 |
| Autoignition Temperature | 424°C |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | III |
| HS Code | 29241900 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 |
| toxic compounds or compounds which causing chronic effects | |
| Hazard Classifications | Acute Tox. 3 Oral |
| Acute Tox. 4 Dermal | |
| Acute Tox. 4 Inhalation | |
| Carc. 1B | |
| Eye Irrit. 2 | |
| Muta. 1B | |
| Repr. 2 | |
| Skin Irrit. 2 | |
| Skin Sens. 1 | |
| STOT RE 1 Oral | |
| Hazardous Substances Data | 79-06-1(Hazardous Substances Data) |
| Toxicity | LD50 i.p. in mice: 170 mg/kg (Peterson, Sheth) |
| IDLA | 60 mg/m3 |
Product Application of Acrylamide (CAS#79-06-1)
More than 90% of acrylamide is utilized in the production of polyacrylamide (PAM), while the remaining portion is used to manufacture N-methylolacrylamide (NMA) and other related monomers. Among its applications, approximately 60% of PAM is consumed in water treatment, 20% in the pulp and paper industry, and 10% in mineral processing.
Acrylamide-based polymers are widely applied in liquid-solid separation processes, where they function as flocculants in mineral processing, wastewater treatment, and water purification, helping to reduce sludge volume. They are also used as additives in the production of paper, paperboard, leather, and coatings. In the paper industry, PAM serves as a retention aid during wet-end processing and contributes to wet strength performance.
Additionally, acrylamide is used in the production of synthetic resins as pigment binders for textile and leather applications, as well as in enhanced oil recovery processes. Other applications include protein electrophoresis (PAGE), dye synthesis, and the preparation of copolymers for contact lenses. It should be noted that acrylamide is considered a substance that may pose carcinogenic risks to humans.
