Shikimic acid CAS#138-59-0
High Water Solubility for Easy Formulation: As a white crystalline powder that dissolves readily in water, shikimic acid is convenient for processing and formulation in pharmaceutical and biochemical applications.
Naturally Derived from Renewable Plant Sources: Extracted mainly from star anise, Liquidambar fruits, and pine needles, it is a plant-based compound that meets the growing demand for natural and sustainable raw materials.
Biologically Important Metabolite: As a key metabolite in plants and microorganisms, shikimic acid plays an essential role in biochemical pathways, making it highly valuable for pharmaceutical synthesis and research.
Multiple Reliable Extraction Sources: The availability of several botanical sources ensures stable supply options and supports large-scale industrial production.
Products Description of Shikimic Acid CAS#138-59-0
Shikimic acid is a white crystalline solid that dissolves readily in water. It was named after Japanese shikigrass, the plant from which it was first isolated. As an important metabolite found in plants and microorganisms, shikimic acid plays a key biological role. Traditionally, it has been primarily obtained from the dried mature fruits of Illicium species, commonly known as Japanese aniseed. In recent years, additional extraction sources have been reported, including the fruits of Liquidambar formosana and pine needles.
Parameters
| Melting point | 185-187 °C (lit.) |
| Alpha | -180 º (c=4, H2O 25 ºC) |
| Boiling point | 225.11°C (rough estimate) |
| Density | 1.52 g/cm3 (27.2℃) |
| Vapor pressure | 0Pa at 25℃ |
| Refractive index | -180 ° (C=1, H2O) |
| Storage temp. | 2-8°C |
| Solubility | 180g/l |
| Form | Powder |
| Pka | pK (14.1°) 5.19 |
| Color | White to light beige or light gray |
| Optical activity | [α]/D -180.0±5.0°, c = 4 in H2O |
| Water Solubility | 18 g/100 mL (20 ºC) |
| Sensitive | Hygroscopic |
| Merck | 148480 |
| BRN | 4782717 |
| InChIKey | JXOHGGNKMLTUBP-HSUXUTPPSA-N |
| LogP | -1.5 at 21℃ and pH1 |
| Surface tension | 49.86mN/m at 1g/L and 20℃ |
| CAS DataBase Reference | 138-59-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Shikimic acid(138-59-0) |
| IARC | 3 (Vol. 40, Sup 7) 1987 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | GW4600000 |
| F | 45726 |
| HS Code | 29181980 |
| Hazardous Substances Data | 138-59-0(Hazardous Substances Data) |
| Toxicity | LD5 i.p. in mice: 1000 mg/kg (Evans, Osman) |
Product Application of Shikimic Acid CAS#138-59-0
Shikimic acid serves as an important precursor in the synthesis of various alkaloids, aromatic amino acids, indole derivatives, and chiral pharmaceuticals. In recent years, it has been widely used as the starting material for the production of oseltamivir (the active component of Tamiflu), a neuraminidase inhibitor employed in the treatment and prevention of influenza A and influenza B.
It is also applied in the development of antitumor agents and functions as a key intermediate in the synthesis of anticancer drugs such as dioxin derivatives and glyoxalase inhibitors.
In addition, shikimic acid is used as a reference standard for the quantitative analysis of shikimic acid content in root apex tissues, and as a substrate in shikimic acid kinase activity assays.
