Curcumin CAS#458-37-7
Powerful Antioxidant – Curcumin prevents oxidative stress by inhibiting nitric oxide (NO) production and reducing markers of oxidative damage, such as 3-nitrotyrosine (3-NT).
Strong Anti-Inflammatory Activity – It suppresses the release of histamine and inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8), reducing inflammation in both cellular and animal models.
Antitumor Effects – Curcumin decreases tumor formation in mouse skin and reduces the number of preneoplastic lesions and neoplasms in animal models.
Protective in Allergic and Cardiovascular Conditions – It mitigates histopathological changes in nasal mucosa, reduces symptoms of rhinitis, and shows protective effects against cardiovascular oxidative stress.
Product Description of Curcumin CAS#458-37-7
Curcumin is the primary yellow pigment found in turmeric and curry, known for its antioxidant, anti-inflammatory, and antitumor properties. It effectively inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin also suppresses the release of histamine and inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IL-8, from HMC-1 mast cells.
In vivo studies show that curcumin lowers serum levels of histamine and TNF-α, prevents histopathological changes in the nasal mucosa, and reduces sneezing and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Additionally, curcumin (100 or 200 mg/kg) inhibits the accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in the hearts of mice. Topical application (1–10 μmol) decreases the number of tumors induced by phorbol 12-myristate 13-acetate (TPA) in mouse skin, while dietary administration reduces tongue neoplasms and preneoplastic lesions caused by 4-nitroquinoline 1-oxide (4-NQO) in rats.
Parameters
| Melting point | 183 °C |
| Boiling point | 418.73°C (rough estimate) |
| Density | 0.93 |
| Vapor density | 13 (vs air) |
| Refractive index | 1.4155-1.4175 |
| Fp | 208.9±23.6 °C |
| Storage temp | 2-8°C |
| Solubility | ethanol: 10 mg/mL |
| Pka | 8.09(at 25℃) |
| Form | powder |
| Colour Index | 75300 |
| Color | orange |
| Odor | Odorless |
| PH Range | Yellow (7.8) to red-brown (9.2) |
| biological source | Curcuma longa (Turmeric) |
| Water Solubility | Slightly soluble (hot) |
| λmax | 430nm |
| Merck | 142,673 |
| BRN | 2306965 |
| Concentration | 1 mCi/ml |
| Solvent | Ethanol |
| Specific Activity | 5-15 Ci/mmol |
| Stability | Stable, but may be light sensitive. Incompatible with strong oxidizing agents. |
| Major Application | Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer |
| InChIKey | VFLDPWHFBUODDF-FCXRPNKRSA-N |
| LogP | 3.290 (est) |
| CAS DataBase Reference | 458-37-7(CAS DataBase Reference) |
| EPA Substance Registry System | Curcumin (458-37-7) |
Safety Information
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 3 |
| RTECS | MI5230000 |
| Hazard Note | Irritant |
| TSCA | Yes |
| HS Code | 29145000 |
| Hazardous Substances Data | 458-37-7(Hazardous Substances Data) |
| Toxicity | LD50 Oral-Rat-12.200 mg/kg |
Product Application of Curcumin CAS#458-37-7
Curcumin is a natural phenolic compound with potent anti-tumor, anti-inflammatory, and antioxidant properties. It induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Curcumin has been reported to suppress the production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. It is a strong inhibitor of EGFR tyrosine kinase and IκB kinase, and also inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase, and lipoxygenase.
Curcumin readily penetrates the cytoplasm of cells, accumulating in membranous structures such as the plasma membrane, endoplasmic reticulum, and nuclear envelope, enhancing its biological activity.
