Arbutin CAS#497-76-7
Potent Tyrosinase Inhibitor – Arbutin effectively inhibits human tyrosinase activity in melanocytes, helping reduce melanin formation and treat hyperpigmentation.
Strong Antioxidant Protection – It protects cells from free radical–induced damage, preventing hemolysis and improving skin fibroblast viability.
Powerful Anti-Inflammatory Activity – Arbutin suppresses inflammatory cytokines (IL-1β, IL-6, TNF-α) in vivo, demonstrating significant anti-inflammatory effects.
Effective Skin Brightening and Depigmenting Agent – Widely used in formulations for hyperpigmentation disorders, supporting skin whitening and tone-evening applications.
Product Description of Arbutin CAS#497-76-7
Arbutin is a glycosylated form of hydroquinone naturally found in Arctostaphylos plants and exhibits a range of biological activities, including tyrosinase inhibition, antioxidant effects, and anti-inflammatory properties. It effectively suppresses human tyrosinase activity in crude enzyme preparations isolated from melanocytes (IC50 values of 5.7 and 18.9 mM using L-tyrosine and L-DOPA as substrates, respectively) as well as in intact melanocytes (IC50 = 0.5 mM).
At a concentration of 50 μM, arbutin inhibits hemolysis induced by the free radical generator AAPH in sheep erythrocytes, and at concentrations above 125 μM, it prevents AAPH-induced reductions in cell viability in cultured human skin fibroblasts. In an LPS-induced rat model of acute lung injury, arbutin (50 mg/kg) suppresses increases in IL-1β, IL-6, and TNF-α levels in both lung tissue and serum. Formulations containing arbutin have been widely applied in the treatment of hyperpigmentation disorders.
Parameters
| Melting point | 195-198 °C |
| alpha | -64 º (c=3) |
| Boiling point | 375.31°C (rough estimate) |
| density | 1.3582 (rough estimate) |
| refractive index | -65.5 ° (C=4, H2O) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 50 mg/mL hot, clear |
| form | Solid |
| pka | 10.10±0.15(Predicted) |
| color | White |
| optical activity | [α]/D -64.0±2.0°, c = 3 in H2O |
| biological source | synthetic or plant |
| Water Solubility | 10-15 g/100 mL at 20 ºC |
| Sensitive | Hygroscopic |
| Merck | 14,773 |
| BRN | 89673 |
| Stability: | Stable. Hygroscopic - store under dry nitrogen. |
| InChIKey | BJRNKVDFDLYUGJ-RMPHRYRLSA-N |
| LogP | -1.35 |
| CAS DataBase | 497-76-7(CAS DataBase Reference) |
| Reference | |
| EPA Substance | .beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7) |
| Registry System |
Safety Informatio
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS | CE8863000 |
| F | 2003/10/23 |
| HS Code | 29389090 |
| Hazardous | 497-76-7(Hazardous Substances Data) |
| Substances Data |
Product Application of Arbutin CAS#497-76-7
Arbutin is applied in diuretic and anti-infective medications for the urinary system. It is also used as a stabilizer in color photographic developing processes. In cosmetic formulations, arbutin is widely utilized for skin whitening, freckle reduction, and hair care applications.
