N,N-Dimethylaniline CAS#121-69-7
Versatile Tertiary Amine Structure: Functions as a tertiary amine with strong reactivity, making it useful in various chemical synthesis processes.
Good Solubility in Organic Solvents: Highly soluble in ethanol, chloroform, ether, and aromatic solvents, supporting flexible formulation and processing.
Suitable Physical Form for Handling: Liquid state with stable properties allows for convenient storage, transfer, and industrial use.
Widely Applicable Chemical Intermediate: Commonly used as an intermediate in dyes, pharmaceuticals, and other organic chemical applications.
N,N-Dimethylaniline CAS#121-69-7
N,N-Dimethylaniline is a tertiary amine in which two hydrogen atoms on the amino group of aniline are substituted by methyl groups. It is classified as both a tertiary amine and a dimethylaniline derivative. The compound appears as a pale yellow to light brown oily liquid with a strong, pungent odor. It is readily soluble in organic solvents such as ethanol, chloroform, ether, and aromatic hydrocarbons, and only slightly soluble in water.
N,N-Dimethylaniline Chemical Properties
| Melting point | 1.5-2.5 °C (lit.) |
| Boiling point | 193-194 °C (lit.) |
| density | 0.956 g/mL at 25 °C (lit.) |
| vapor density | 3 (vs air) |
| vapor pressure | 2 mm Hg ( 25 °C) |
| refractive index | n20/D 1.557(lit.) |
| Fp | 158 °F |
| storage temp. | Store below +30°C. |
| solubility | 1.2g/l |
| pka | 5.15(at 25℃) |
| form | Liquid |
| color | Clear yellow |
| PH | 7.4 (1.2g/l, H2O, 20℃) |
| Relative polarity | 0.179 |
| explosive limit | 1.2-7%(V) |
| Water Solubility | 1 g/L (20 ºC) |
| Merck | 143234 |
| BRN | 507140 |
| Henry's Law Constant | 4.98(x 10-6 atm?m3/mol) at 20 °C (approximate - calculated from water solubility and vapor pressure) |
| Dielectric constant | 4.4 |
| Exposure limits | NIOSH REL: TWA 5 ppm (25 mg/m3), STEL 10 ppm (50 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 5 ppm; ACGIH TLV: TWA 5 ppm, STEL 10 ppm (adopted). |
| Stability: | Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides, chloroformates, halogens. Combustible. |
| InChIKey | JLTDJTHDQAWBAV-UHFFFAOYSA-N |
| LogP | 1.171 at 35℃ |
| CAS DataBase Reference | 121-69-7(CAS DataBase Reference) |
| IARC | 3 (Vol. 57) 1993 |
| NIST Chemistry Reference | Benzenamine, N,N-dimethyl-(121-69-7) |
| EPA Substance Registry System | N,N-Dimethylaniline (121-69-7) |
Safety Information
| Hazard Codes | T,N |
| Risk Statements | 61-20/21-51/53-40-23/24/25 |
| Safety Statements | 53-45-61-36/37-28A-28 |
| RIDADR | UN 2253 6.1/PG 2 |
| OEB | A |
| OEL | TWA: 5 ppm (25 mg/m3), STEL: 10 ppm (50 mg/m3) [skin] |
| WGK Germany | 3 |
| RTECS | BX4725000 |
| F | 8 |
| Autoignition Temperature | 370 °C DIN 51794 |
| TSCA | Yes |
| HS Code | 2921 42 00 |
| HazardClass | 6.1 |
| PackingGroup | II |
| Hazardous Substances Data | 121-69-7(Hazardous Substances Data) |
| Toxicity | LD50 orally in rats: 1.41 ml/kg (Smyth) |
| IDLA | 100 ppm |
Product Applications of N,N-Dimethylaniline (CAS No. 121-69-7)
N,N-Dimethylaniline is widely used in the production of dyes, as a solvent, as a reagent in methylation reactions, and as a curing agent in fiberglass-reinforced resins.
It is an important intermediate in the dye industry and can be used to synthesize products such as alkaline yellow, crystal violet 5BN, basic magenta green, basic lake blue BB, basic brilliant blue R, cationic red 2BL, brilliant red 5GN, violet 3BL, and brilliant blue. In the pharmaceutical field, it serves as a raw material for the manufacture of drugs including cefazolin V, sulfamonomethoxine, sulfadoxine, and fluorocytosine. In addition, it can be used as an intermediate in vanillin production, as a stabilizer in colorimetric peroxidase determination, and as a reagent in chemical synthesis.
