Metformin hydrochloride CAS#1115-70-4
Effective Oral Hypoglycemic Agent: Metformin hydrochloride is a well-established biguanide oral hypoglycemic drug widely used for blood glucose management.
Promotes Glycogen Formation: It helps promote the conversion of glucose into glycogen, supporting better glucose utilization and storage.
Reduces Glucagon Secretion: The product works by reducing glucagon secretion from pancreatic A cells, which contributes to improved blood sugar control.
Non-Insulin Secretagogue Mechanism: A key advantage is that it does not stimulate pancreatic β-cells to secrete insulin, making its mechanism distinct and suitable for specific therapeutic applications.
Product Description of Metformin Hydrochloride CAS#1115-70-4
Metformin hydrochloride is a biguanide oral hypoglycemic drug, also known as Glucophage and Medicon. Its hypoglycemic effect is slightly weaker than phenformin, but it effectively helps control blood glucose levels.
The primary mechanism of metformin hydrochloride is to reduce glucagon secretion from pancreatic A cells and promote the conversion of glucose into glycogen, supporting efficient glucose utilization. A notable feature of this drug is that it does not stimulate pancreatic β-cells to secrete insulin, making it suitable for patients requiring non-insulin-dependent blood sugar management.
Parameters
| Melting point | 223-226 °C(lit.) |
| density | 1.36[at 20℃] |
| vapor pressure | 0.001Pa at 25℃ |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | Freely soluble in water, slightly soluble in alcohol, practically insoluble in acetone and in methylene chloride |
| pka | 12.4[at 20 ℃] |
| form | Powder |
| color | White |
| Water Solubility | Soluble in water (50 mg/ml), ethanol, and DMSO (50 mM). |
| λmax | 233nm(H2O)(lit.) |
| Merck | 145938 |
| BCS Class | 3 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months. |
| InChIKey | OETHQSJEHLVLGH-UHFFFAOYSA-N |
| LogP | -3.5 at 20℃ |
| CAS DataBase Reference | 1115-70-4(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn,T,F |
| Risk Statements | 22-36/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-45-36/37-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | DU1800000 |
| HS Code | 29252900 |
| Hazardous Substances Data | 1115-70-4(Hazardous Substances Data) |
| Toxicity | LD50 in rats (mg/kg): 1000 orally, 300 s.c. (Rx Bulletin) |
Product Application of Metformin Hydrochloride CAS#1115-70-4
Metformin hydrochloride is an oral hypoglycemic agent widely used to manage type 2 diabetes. It effectively reduces fasting and postprandial blood glucose levels, and can lower HbA1c by 1% to 2%.
The primary mechanisms of action include:
Increasing insulin sensitivity in peripheral tissues, enhancing insulin-mediated glucose uptake.
Promoting glucose utilization in non-insulin-dependent tissues, such as the brain, red blood cells, renal medulla, intestines, and skin.
Inhibiting hepatic gluconeogenesis, thereby reducing glucose production in the liver.
Reducing glucose absorption by intestinal epithelial cells.
Function and Indication: This product is suitable for mild type 2 diabetes.
Metformin hydrochloride acts as an antidiabetic agent that lowers blood glucose levels and improves insulin sensitivity, with its metabolic effects, including inhibition of hepatic gluconeogenesis, mediated through the LKB1-AMPK (AMP-activated protein kinase) pathway.
