Fluconazole CAS#86386-73-4
Broad-Spectrum Antifungal Activity – Fluconazole provides effective inhibition against a wide range of fungal pathogens, making it suitable for multiple antifungal applications.
Systemic Antifungal Efficacy – As a systemic antifungal agent, it delivers reliable therapeutic performance throughout the body for deep and systemic fungal infections.
Highly Selective Mechanism of Action – It selectively inhibits fungal cytochrome P-450-dependent enzymes, ensuring targeted antifungal activity with high specificity.
Potent Inhibition of Fungal Sterol Synthesis – Fluconazole strongly and specifically blocks fungal sterol biosynthesis, disrupting fungal cell membrane formation and preventing growth.
Parameters
| Melting point | 138-140°C |
| Boiling point | 579.8±60.0 °C(Predicted) |
| density | 1.05 |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: 5 mg/mL |
| form | solid |
| pka | pKa 1.76±0.1(H2O t=24 I=0.1(NaCl)) (Uncertain) |
| color | White to Off-White |
| Water Solubility | 1g/L(temperature not stated) |
| Merck | 144122 |
| BCS Class | 1,3 |
| InChI | InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2 |
| InChIKey | RFHAOTPXVQNOHP-UHFFFAOYSA-N |
| SMILES | C1(C=CC(F)=CC=1F)C(O)(CN1N=CN=C1)CN1N=CN=C1 |
| CAS DataBase Reference | 86386-73-4(CAS DataBase Reference) |
Safety Information
| Hazard Codes | Xn,Xi,T,F |
| Risk Statements | 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-36/37/39-24/25-45-36/37-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | XZ4810000 |
| HS Code | 29336990 |
| Hazardous Substances Data | 86386-73-4(Hazardous Substances Data) |
Product Application of Fluconazole CAS#86386-73-4
Fluconazole is a broad-spectrum triazole antifungal drug with an antibacterial spectrum similar to ketoconazole. It is long-acting, highly effective against deep fungal infections, and provides strong antifungal activity with good oral absorption. It is mainly used for the treatment of candidiasis and cryptococcosis, and is also effective for oropharyngeal candidiasis in cancer patients.
