2-Methylimidazole CAS#693-98-1
Good Solubility in Polar Systems: Highly soluble in water, alcohols, and ketones, supporting versatile use in various formulations and reactions.
Stable Crystalline Form: Available as a white to light yellow crystalline powder, ensuring consistent quality and ease of handling.
Efficient Chemical Reactivity: Imidazole structure provides useful reactivity, making it suitable for organic synthesis and intermediate applications.
Wide Industrial Applicability: Commonly used in pharmaceuticals, resins, and chemical synthesis due to its adaptable chemical properties.
2-Methylimidazole (CAS No. 693-98-1) 2-Methylimidazole appears as a white to light yellow crystalline powder with an amine-like odor. It is highly soluble in polar organic solvents, readily dissolving in water, alcohols, and ketones, while being insoluble in ether and cold benzene. The compound may cause irritation to the skin and mucous membranes. The oral LD₅₀ in mice is 1400 mg/kg.
2-Methylimidazole Chemical Properties
| Melting point | 142-143 °C (lit.) |
| Boiling point | 267-268 °C (lit.) |
| bulk density | 550kg/m3 |
| density | 1.0500 (rough estimate) |
| vapor pressure | <1 mm Hg ( 0 °C) |
| refractive index | 1.4970 (estimate) |
| Fp | 155 °C |
| storage temp. | 2-8°C |
| solubility | 780g/l |
| pka | 14.44±0.10(Predicted) |
| form | Crystalline Powder |
| color | White to light yellow |
| PH | 10.5-11.5 (100g/l, H2O, 20℃) |
| PH Range | 10.5 |
| Water Solubility | Soluble in water and ethanol. |
| BRN | 1368 |
| InChI | 1S/C4H6N2/c1-4-5-2-3-6-4/h2-3H,1H3,(H,5,6) |
| InChIKey | LXBGSDVWAMZHDD-UHFFFAOYSA-N |
| SMILES | Cc1ncc[nH]1 |
| LogP | 0.22 at 25℃ |
| CAS DataBase Reference | 693-98-1(CAS DataBase Reference) |
| IARC | 2B (Vol. 101) 2013 |
| NIST Chemistry Reference | 1H-Imidazole, 2-methyl-(693-98-1) |
| EPA Substance Registry System | 2-Methylimidazole (693-98-1) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 22-34 |
| Safety Statements | 26-36/37/39-45-25 |
| RIDADR | UN 3259 8/PG 2 |
| WGK Germany | 2 |
| RTECS | NI7175000 |
| Autoignition Temperature | >600 °C DIN 51794 |
| Hazard Note | Harmful/Corrosive |
| TSCA | TSCA listed |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29332990 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 |
| toxic compounds or compounds which causing chronic effects | |
| Hazard Classifications | Acute Tox. 4 Oral |
| Carc. 2 | |
| Eye Dam. 1 | |
| Repr. 1B | |
| Skin Corr. 1C | |
| Hazardous Substances Data | 693-98-1(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 1500 mg/kg |
Product Applications of 2-Methylimidazole (CAS No. 693-98-1)
2-Methylimidazole is a monomethylated imidazole that serves as a key building block for the synthesis of various biologically active compounds. It, along with other imidazole derivatives, can also be used as a catalyst in the refolding of enhanced colored fluorescent proteins. In addition, 2-methylimidazole has been identified as a byproduct of fermentation and can be detected in certain foods as well as in mainstream and sidestream tobacco smoke.
