N,N-Dimethylformamide CAS#68-12-2
Versatile Solvent – Dimethylformamide (DMF) dissolves in both water and organic solvents, making it highly adaptable for use across a variety of chemical processes.
Industrial Applications – Widely employed in the production of acrylic fibers, pharmaceuticals, dyes, petroleum products, and other organic chemicals.
Specialized Uses – Functions as a gasoline additive and is also utilized in electronics manufacturing, highlighting its utility in multiple technical fields.
Efficient Physical Properties – With a boiling point of 153°C, low freezing point of -61°C, and moderate vapor pressure, DMF is convenient for high-temperature reactions and industrial processes requiring stable liquid solvents.
Products Description of N,N-Dimethylformamide CAS#68-12-2
N,N-Dimethylformamide (DMF) is a colorless, flammable liquid with a characteristic fishy odor. It has a molecular weight of 73.11, a boiling point of 153°C, a freezing point of -61°C, a flash point of 58°C, and a vapor pressure of 3 mmHg at 20°C. DMF is soluble in both water and a wide range of organic solvents. It presents hazards including flammability (explosive limits: LEL 2.2%, UEL 15.2%), toxicity, carcinogenicity, mutagenicity, and potential for skin irritation. It is extensively used as a solvent in the production of acrylic fibers, pharmaceuticals, dyes, petroleum products, and other organic chemicals, and also finds applications as a gasoline additive and in electronic manufacturing.
Parameters
| Melting point | -61 °C (lit.) |
| alpha | 0.94 º |
| Boiling point | 153 °C (lit.) |
| density | 0.944 g/mL (lit.) |
| vapor density | 2.5 (vs air) |
| vapor pressure | 2.7 mm Hg ( 20 °C) |
| refractive index | n20/D 1.430(lit.) |
| Fp | 136 °F |
| storage temp. | Store at +5°C to +30°C. |
| solubility | water: miscible |
| pka | -0.44±0.70(Predicted) |
| form | liquid |
| color | APHA: ≤15 |
| PH | 7 (200g/l, H2O, 20℃) |
| Odor | Faint, ammonia-like odor detectable at 100 ppm |
| Relative polarity | 0.386 |
| Odor Threshold | 1.8ppm |
| explosive limit | 2.2-16%(V) |
| Water Solubility | soluble |
| λmax | λ: 270 nm Amax: 1.00 |
| λ: 275 nm Amax: 0.30 | |
| λ: 295 nm Amax: 0.10 | |
| λ: 310 nm Amax: 0.05 | |
| λ: 340-400 nm Amax: 0.01 | |
| Sensitive | Hygroscopic |
| Merck | 143243 |
| BRN | 605365 |
| Exposure limits | NIOSH REL: TWA 10 ppm (30 mg/m3), IDLH 500 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted). |
| Dielectric constant | 36.71 |
| InChIKey | ZMXDDKWLCZADIW-UHFFFAOYSA-N |
| LogP | -1.01 |
| Surface tension | 35.20mN/m at 298.15K |
| Surface tension | 37.1mN/m at 20°C |
| CAS DataBase Reference | 68-12-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Formamide, N,N-dimethyl-(68-12-2) |
| IARC | 2A (Vol. 47, 71, 115) 2018 |
| EPA Substance Registry System | N,N-Dimethylformamide (68-12-2) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 61-20/21-36 |
| Safety Statements | 53-45 |
| RIDADR | UN 2265 3/PG 3 |
| OEB | A |
| OEL | TWA: 10 ppm (30 mg/m3) [skin] |
| WGK Germany | 1 |
| RTECS | LQ2100000 |
| F | 46091 |
| Autoignition Temperature | 445 °C |
| Hazard Note | Toxic |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29241990 |
| Hazardous Substances Data | 68-12-2(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (ml/kg): 6.8, 7.6 orally; 6.2, 4.7 i.p. (Bartsch) |
| IDLA | 500 ppm |
Product Application of N,N-Dimethylformamide CAS#68-12-2
N,N-Dimethylformamide (DMF) is primarily used as a solvent and extractant, especially for salts and high-molecular-weight compounds. Its versatility stems from a unique combination of physical and chemical properties, including low molecular mass, high dielectric constant, electron-donor capability, and complex-forming ability. Although its role as a reagent in chemical synthesis is less commercially significant, anhydrous DMF has been employed as a solvent in the preparation of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic agent) and the fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene]. It also serves as a solvent medium in various organic reduction reactions.
