Bronopol CAS#52-51-7
Effective Antimicrobial Agent – Bronopol acts as a preservative and biocide, preventing microbial growth in various formulations.
Versatile Usage – It can be incorporated into multiple products, including lubricants and cosmetic or pharmaceutical preparations.
Water-Soluble – Its solubility in water allows easy formulation and dispersion in aqueous products.
Stability in Formulations – Bronopol maintains antimicrobial efficacy over time, supporting long shelf-life of the products it protects.
Bronopol CAS#52-51-7
Bronopol is a formaldehyde-releasing compound that has been reported as a potential allergen among dairy workers. In a recent case, it was present in a lubricant jelly used for ultrasound procedures and triggered contact dermatitis in a veterinary surgeon.
Bronopol Chemical Properties
| Melting point | 130-133 °C(lit.) |
| Boiling point | 358.0±42.0 °C(Predicted) |
| density | 2.0002 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| Fp | 167°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: soluble100mg/mL, clear, colorless to faintly yellow |
| pka | 12.02±0.10(Predicted) |
| form | Crystals or Crystalline Powder |
| color | White to yellow |
| Odor | odorless |
| Water Solubility | 25 g/100 mL (22 ºC) |
| Merck | 141447 |
| BRN | 1705868 |
| Stability: | Stable. Hygroscopic. Incompatible with strong oxidizing agents, strong bases, strong reducing agents, acid chlorides and anhydrides, moisture. |
| Major Application | agriculture |
| cleaning products | |
| cosmetics | |
| environmental | |
| food and beverages | |
| personal care | |
| Cosmetics Ingredients Functions | PRESERVATIVE |
| Cosmetic Ingredient Review (CIR) | Bronopol (52-51-7) |
| InChI | 1S/C3H6BrNO4/c4-3(1-6,2-7)5(8)9/h6-7H,1-2H2 |
| InChIKey | LVDKZNITIUWNER-UHFFFAOYSA-N |
| SMILES | OCC(Br)(CO)[N+]([O-])=O |
| LogP | 1.150 (est) |
| CAS DataBase Reference | 52-51-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Bronopol(52-51-7) |
| EPA Substance Registry System | Bronopol (52-51-7) |
Safety Information
| Hazard Codes | Xn,N |
| Risk Statements | 21/22-37/38-41-50 |
| Safety Statements | 26-37/39-61-36/37/39 |
| RIDADR | UN 3241 4.1/PG 3 |
| WGK Germany | 2 |
| RTECS | TY3385000 |
| F | 4.2-8-9-21 |
| TSCA | TSCA listed |
| HazardClass | 4.1 |
| PackingGroup | III |
| HS Code | 29055999 |
| Storage Class | 4.1B - Flammable solid hazardous materials |
| Hazard Classifications | Acute Tox. 4 Dermal |
| Acute Tox. 4 Oral | |
| Aquatic Acute 1 | |
| Aquatic Chronic 1 | |
| Eye Dam. 1 | |
| Skin Irrit. 2 | |
| STOT SE 3 | |
| Hazardous Substances Data | 52-51-7(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (mg/kg): 350, 400 orally (Croshaw) |
Product Application of Bronopol CAS#52-51-7
Bronopol is used at concentrations of 0.01–0.1% w/v as an antimicrobial preservative, either alone or in combination with other preservatives, in topical pharmaceutical products, cosmetics, and personal care items. The typical usage level is 0.02% w/v.
