Rifampicin CAS#13292-46-1
Broad-Spectrum Antibacterial Activity: Rifampicin is a broad-spectrum rifamycin antibiotic effective against Mycobacterium tuberculosis, Gram-positive bacteria, Gram-negative bacteria, and certain viruses.
Strong Anti-Tuberculosis Efficacy: It provides a powerful antibacterial effect against tuberculosis bacteria, making it a core agent in anti-TB therapy.
Synergistic Combination Therapy: When used in combination with other anti-tuberculosis drugs, it delivers a synergistic therapeutic effect, improving overall treatment outcomes.
Helps Delay Drug Resistance: Combination use can effectively delay the development of drug-resistant strains, supporting long-term clinical efficacy.
Product Description of Rifampicin CAS#13292-46-1
Rifampicin (INN: Rifampicin) is a broad-spectrum antibiotic belonging to the rifamycin class. It demonstrates strong antibacterial activity against Mycobacterium tuberculosis and is also effective against a range of Gram-positive bacteria, Gram-negative bacteria, and certain viruses.
The product appears as a red to dark red crystalline powder and is insoluble in water. It is commonly formulated into oral capsules or tablets for clinical use.
When administered in combination with other anti-tuberculosis agents, rifampicin provides a synergistic therapeutic effect and helps delay the development of drug-resistant strains, making it a key component in modern tuberculosis treatment regimens.
Parameters
| Melting point | 183°C (dec.) |
| Boiling point | 761.02°C (rough estimate) |
| density | 1.1782 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | 2-8°C |
| solubility | chloroform: soluble50mg/mL, clear |
| pka | 1.7, 7.9(at 25℃) |
| form | crystalline |
| color | faint red to very dark red |
| Water Solubility | Soluble in DMSO or methanolSoluble in water, ethyl acetate, chloroform, methanol, tetrahydrofuran and dimethyl sulfoxide. |
| Merck | 148216 |
| BRN | 5723476 |
| Specific Activity | Antibacterial |
| BCS Class | 2 |
| Stability: | Hygroscopic, Light Sensitive |
| IARC | 3 (Vol. 24, Sup 7) 1987 |
| EPA Substance Registry System | Rifampin (13292-46-1) |
Safety Information
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-36/38 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| RTECS | VJ7000000 |
| F | 39742 |
| HS Code | 29419000 |
| Hazardous Substances Data | 13292-46-1(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (mg/kg): 885, 1720 orally; 260, 330 i.v.; 640, 550 i.p. (Fürész) |
Product Application of Rifampicin CAS#13292-46-1
Rifampicin is a broad-spectrum antibiotic with antibacterial and bactericidal activity against Mycobacterium tuberculosis, Gram-positive bacteria, and certain Gram-negative bacteria.
It is primarily used in the treatment of drug-resistant tuberculosis infections and drug-resistant Staphylococcus aureus infections, and also shows therapeutic value in the treatment of leprosy.
As a cell-penetrating, full-spectrum bactericidal agent, rifampicin exhibits strong bactericidal potency, particularly against mycobacteria as well as Gram-positive and Gram-negative bacteria.
In addition to direct pharmaceutical use, it is also applied as a pharmaceutical intermediate with broad-spectrum antibacterial activity, demonstrating excellent efficacy against Gram-positive cocci and Mycobacterium tuberculosis. Its antibacterial spectrum remains consistent with that of rifampicin.
