Gomisin A CAS#58546-54-6
Schisandrol B is a lignan compound originally isolated from Schisandra chinensis and is known for its hepatoprotective properties. It enhances the expression of pregnane X receptor (PXR) target genes associated with bile acid metabolism, including Cyp3a11, Ugt1a1, Oatp2, and Mrp3 in mouse liver, as well as CYP3A4, UGT1A1, and OATP2 in HEK293T cells.
In addition, Schisandrol B has been shown to protect against lithocholic acid-induced hepatic necrosis and intrahepatic cholestasis in wild-type mice, while reducing mortality in mouse cholestasis models when administered at 100 mg/kg twice daily. It also supports liver regeneration after partial hepatectomy and provides protective effects against acetaminophen-induced hepatotoxicity.
Gomisin A Chemical Properties
| Melting point | 88.5°C |
| Boiling point | 454.79°C (rough estimate) |
| density | 1.1772 (rough estimate) |
| refractive index | 1.5300 (estimate) |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO : 50 mg/mL (120.06 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | powder to crystal |
| pka | 14.58±0.40(Predicted) |
| color | White to Light yellow |
| biological source | Schisandra chinensis |
| InChI | 1S/C23H28O7/c1-12-7-13-8-16-20(30-11-29-16)22(28-6)17(13)18-14(10-23(12,2)24)9-15(25-3)19(26-4)21(18)27-5/h8-9,12,24H,7,10-11H2,1-6H3/t12-,23-/m0/s1 |
| InChIKey | ZWRRJEICIPUPHZ-MYODQAERSA-N |
| SMILES | C[C@]1([H])[C@@](C)(O)CC2=C(C(OC)=C(OC)C(OC)=C2)C3=C(OC)C4=C(OCO4)C=C3C1 |
| LogP | 4.770 (est) |
| Safety Statements | 24/25 |
| WGK Germany | WGK 3 |
| HS Code | 29329990 |
| Storage Class | 11 - Combustible Solidsb |
Product Application of Gomisin A CAS#58546-54-6
Schizandrol B demonstrates significant protective effects against ET-1-induced dysfunction in human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs). It also exhibits anti-cholestatic activity.
