Poly(methylhydrosiloxane) CAS#63148-57-2
Highly Efficient Reducing Agent – Delivers excellent reduction performance for esters, aldehydes, ketones, phosphine oxides, and other organic compounds.
Versatile Organic Synthesis Applications – Suitable for a wide range of reduction reactions, including conjugate reduction of α,β-unsaturated carbonyl and carboxyl compounds.
Supports Green Chemistry – Enables environmentally friendly amine synthesis through reductive amination, offering an effective alternative to borohydride-based reducing agents.
Ideal for Advanced Chemical Processes – Widely used in modern organic synthesis, making it a valuable reagent for pharmaceutical, fine chemical, and research applications.
Poly(methylhydrosiloxane) CAS#63148-57-2
Poly(methylhydrosiloxane) is an effective reducing agent widely used in organic synthesis. It can reduce esters to alcohols, as well as aldehydes and ketones to their corresponding products. It is also suitable for reducing phosphine oxides to phosphines. In recent years, it has been applied to the conjugate reduction of α,β-unsaturated carbonyl and carboxyl compounds. In addition, poly(methylhydrosiloxane) is used in environmentally friendly amine synthesis through reductive amination, providing an alternative to borohydride-based reducing agents.
Poly(methylhydrosiloxane) Chemical Properties
| Melting point | <-60°C |
| Boiling point | 142 °C(lit.) |
| density | 1.006 g/mL at 25 °C (lit.) |
| vapor pressure | 38 hPa (20 °C) |
| refractive index | n20/D 1.382(lit.) |
| Fp | 204 °C |
| storage temp. | Store below +30°C. |
| solubility | Soluble in most ethereal, chlorinated, or hydrocarbon solvents as well as EtOH, i-PrOH, warm DMF, and warm NMP; insoluble in MeOH, DMSO, acetonitrile, and water |
| form | liquid |
| Specific Gravity | 0.98 |
| PH | 7 (H2O) |
| Appearance | Colorless to light yellow Liquid |
| Water Solubility | Not miscible or difficult to mix in water. |
| InChIKey | KZFYHEHDBPYRMU-UHFFFAOYSA-N |
| SMILES | [Si](C)(C)(C)C.[Si](O)(C)(C)C.[SiH](O)(C)C |
| CAS DataBase Reference | 63148-57-2 |
| EPA Substance Registry System | Siloxanes and Silicones, Me hydrogen (63148-57-2) |
| Hazard Codes | Xi |
| Risk Statements | 10-36/37/38 |
| Safety Statements | 26-36-24/25-23-16 |
| WGK Germany | 3 |
| F | 46316 |
| TSCA | TSCA listed |
| HS Code | 39100000 |
| Storage Class | 10 - Combustible liquids |
Product Application of Poly(methylhydrosiloxane) CAS#63148-57-2
Polymethylhydrosiloxane (PMHS) is an easy-to-handle, cost-effective, low-toxicity, and mild reducing agent. It is widely recognized as an alternative to more expensive or hazardous silanes and siloxanes, and serves as a stoichiometric reducing agent in catalytic organotin-mediated reactions.
PMHS can be cross-linked with metal catalysts at low temperatures to form waterproof membranes. It is widely used as a waterproofing agent for textiles, glass, ceramics, paper, leather, metals, cement, and marble, with particularly extensive applications in textile waterproofing. It also functions as an insulating and cross-linking agent in the paper industry.
In organic synthesis, PMHS is used for the reduction of esters to alcohols in the presence of titanocene dichloride with either n-BuLi or EtMgBr as catalysts. It is also considered a safer alternative to triethoxysilane for the reduction of phosphine oxides to phosphines when catalyzed by Ti(O-i-Pr)₄. In addition, PMHS is widely employed in environmentally friendly amine synthesis through reductive amination as an alternative to borohydride-based reducing agents.
