Benzylamine CAS#100-46-9
Versatile Chemical Intermediate: Widely used as an important intermediate in the synthesis of pharmaceuticals and agrochemicals, including imidacloprid, acetamiprid, and sulfadiazine.
Excellent Solubility Profile: Fully miscible with water, ethanol, and ether, and readily soluble in acetone and benzene, enabling flexible use in various reaction systems.
Stable Physicochemical Properties: Exhibits a well-defined boiling point (185°C) and relative density (0.9813), supporting reliable handling and process control in industrial applications.
Reactive and Functional Organic Base: As an alkaline amine compound, it provides strong reactivity for chemical synthesis and readily forms derivatives for downstream applications.
Product Description of Benzylamine CAS#100-46-9
Benzylamine, also known as α-aminotoluene or moringamine, is a colorless alkaline liquid. Upon exposure to air, it may emit fumes and gradually form white crystalline deposits. The compound has a boiling point of 185°C (90°C at 1.6 kPa), a refractive index (nD50) of 1.5430, and a relative density of approximately 0.981. It is completely miscible with water, ethanol, and ether, and is also soluble in acetone and benzene. Benzylamine is widely used as an intermediate in the production of agrochemicals such as imidacloprid and acetamiprid, as well as in the synthesis of pharmaceutical compounds including sulfadiazine.
Benzylamine Chemical Properties
| Melting point | 10 °C (lit.) |
| Boiling point | 184-185 °C (lit.) |
| density | 0.981 g/mL at 25 °C (lit.) |
| vapor pressure | 1.2 hPa (20 °C) |
| refractive index | n20/D 1.543(lit.) |
| Fp | 140 °F |
| storage temp. | Store below +30°C. |
| solubility | alcohol: miscible |
| form | Liquid |
| pka | 9.33(at 25℃) |
| color | Clear colorless to slightly yellow |
| Odor | Strong ammonia. |
| PH | 11.4 (100g/l, H2O, 20℃) |
| explosive limit | 0.7-8.2%(V) |
| Water Solubility | soluble |
| Sensitive | Air Sensitive |
| Merck | 141125 |
| BRN | 741984 |
| Dielectric constant | 4.6（Ambient） |
| Stability: | Combustible. Incompatible with strong oxidizing agents, strong acids. |
| InChI | 1S/C7H9N/c8-6-7-4-2-1-3-5-7/h1-5H,6,8H2 |
| InChIKey | WGQKYBSKWIADBV-UHFFFAOYSA-N |
| SMILES | NCc1ccccc1 |
| LogP | 1 at 25℃ |
| Surface tension | 37.1mN/m at 293.15K |
| CAS DataBase Reference | 100-46-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Benzylamine(100-46-9) |
| EPA Substance Registry System | Benzylamine (100-46-9) |
Safety Information
| Hazard Codes | C |
| Risk Statements | 21/22-34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 2735 8/PG 2 |
| WGK Germany | 1 |
| RTECS | DP1488500 |
| F | 34 |
| Autoignition Temperature | 405 °C |
| TSCA | TSCA listed |
| HS Code | 2921 49 00 |
| HazardClass | 8 |
| PackingGroup | II |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Acute Tox. 4 Dermal |
| Acute Tox. 4 Oral | |
| Eye Dam. 1 | |
| Skin Corr. 1B | |
| Hazardous Substances Data | 100-46-9(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 552 mg/kg LD50 dermal Rat 1350 mg/kg |
Product Application of Benzylamine CAS#100-46-9
Benzylamine is an important intermediate and versatile building block in chemical synthesis, widely used in the production of pharmaceuticals and crop protection products. It is also utilized in the coatings industry. In analytical chemistry, benzylamine serves as a carrier electrolyte for the separation of alkali, alkaline earth, and ammonium cations in water samples by capillary electrophoresis with indirect UV detection. Additionally, it is employed in the synthesis of cross-linked porous copolymer supports based on N-(p-vinylbenzoyl)-2-methylalanine, styrene, and divinylbenzene. In the textile industry, benzylamine is used in the manufacture of colored dyes. It is also incorporated into topical creams, antifungal formulations, and vitamin products for pharmaceutical applications.
